Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Assessing Depression and GDM in Pregnancy

Diabetologia; ePub 2016 Sep 19; Hinkle, et al

There was a modest association between depressive symptoms early in pregnancy and an increased risk of incident gestational diabetes (GDM), was well as between GDM and subsequent postpartum depression risk, a recent study found. The longitudinal study evaluated 2,477 pregnant women without psychiatric disorders, diabetes or other chronic conditions who were followed throughout pregnancy. Only women with GDM and matched controls were followed up at 6 weeks postpartum (n=162). Depression was assessed in the first and second trimesters and at 6 weeks postpartum. Researchers found:

• There was a significant two-fold increased risk of GDM from the highest quartile of first-trimester depression scores; the second trimester results were similar.

• The risk was stronger and significant in both trimesters among non-obese women, but not for obese women.

• The greatest risk of GDM existed among women with persistently high depression scored in both trimesters.

• GDM was associated with an adjusted 4.62-fold increased risk of subsequent postpartum depression.


Hinkle SN, Buck Louis GM, Rawal S, et al. A longitudinal study of depression and gestational diabetes in pregnancy and the postpartum period. [Published online ahead of print September 19, 2016]. Diabetologia. doi:10.1007/s00125-016-4086-1.