Clinical Edge

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Extremely preterm infants fare better with corticosteroid and magnesium combo

Key clinical point: Antenatal corticosteroids and magnesium sulfate together are associated with better outcomes in extremely preterm children.

Major finding: Children exposed to both corticosteroids and magnesium had 27% reduced risk of severe neurodevelopmental impairment or death, compared with those exposed to only corticosteroids (adjusted odds ratio, 0.73).

Study details: The findings are based on analysis of prospective observational data during 2011-2014 of 3,093 extremely preterm children (22-26 weeks).

Disclosures: The research was funded by the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Center for Advancing Translational Sciences. One author is a consultant for Mednax who has received travel funds. Another author disclosed Catholic Health Professionals of Houston paid honorarium for an ethics talk he gave.


Gentle SJ et al. Obstet. Gynecol. 2020. doi: 10.1097/AOG.0000000000003882.