In postmenopausal women, hormone therapy (HT) may have a minor negative effect on pelvic organ support; however, the effect is likely too small to be clinically relevant. This according to a retrospective observational study of 1,443 postmenopausal women with pelvic floor dysfunction attending a tertiary urogynecology center between January 2012 and March 2015. All participants underwent a clinical examination and information on current or former use of systemic HT and current local estrogen was collected. Researchers found:
- Current HT was significantly associated with sonographically determined descent of the rectal ampulla on univariate analysis.
- Past HT use, duration of HT use, or current vaginal estrogen use was not associated with pelvic organ support.
- On multivariate analysis, the association between current HT and Gh + Pb as well as increased descent of the rectal ampulla on ultrasound, remained significant.
Wasenda EJ, Kamisan IA, Subramaniam N, Dietz PH. Pelvic organ prolapse: Does hormone therapy matter? Menopause. 2017;24(10):1185-1189. doi:10.1097/GME.0000000000000898.