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What Effect Does HT Have on Pelvic Organ Support?

Menopause; 2017 Oct; Wasenda, Kamisan, et al

In postmenopausal women, hormone therapy (HT) may have a minor negative effect on pelvic organ support; however, the effect is likely too small to be clinically relevant. This according to a retrospective observational study of 1,443 postmenopausal women with pelvic floor dysfunction attending a tertiary urogynecology center between January 2012 and March 2015. All participants underwent a clinical examination and information on current or former use of systemic HT and current local estrogen was collected. Researchers found:

  • Current HT was significantly associated with sonographically determined descent of the rectal ampulla on univariate analysis.
  • Past HT use, duration of HT use, or current vaginal estrogen use was not associated with pelvic organ support.
  • On multivariate analysis, the association between current HT and Gh + Pb as well as increased descent of the rectal ampulla on ultrasound, remained significant.


Wasenda EJ, Kamisan IA, Subramaniam N, Dietz PH. Pelvic organ prolapse: Does hormone therapy matter? Menopause. 2017;24(10):1185-1189. doi:10.1097/GME.0000000000000898.