Clinical Edge

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Vascular Dysfunction During Menopausal Transition

Menopause; ePub 2018 Apr 9; Hildreth, et al

Vascular dysfunction across the stages of menopause is associated with greater frequency and severity of menopausal symptoms and lower quality of life, but not depression, according to a recent study. Researchers measured arterial stiffness, endothelial function, menopausal symptoms, depression, and quality of life (QOL) in 138 premenopausal women. They found:

  • Menopausal symptoms, depression, and QOL worsened across menopause stages, particularly in late perimenopausal women.
  • Vasosomatic symptom frequency and general somatic symptom frequency and severity were inversely correlated with carotid artery compliance and FMD.
  • Only correlations with general somatic symptoms were significant after adjusting for multiple comparisons.
  • Total QOL was positively correlated with carotid artery compliance.


Hildreth KL, Ozemek C, Kohrt WM, Blatchford P, Moreau KL. Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life. [Published online ahead of print April 9, 2018]. Menopause. doi:10.1097/GME.0000000000001112.