Higher vaginal estrogenization was prevalent across all age groups and with no decline in age compared to 1960s clinical data, according to a recent study that examined the prevalence and correlates of vaginal estrogenization in postmenopausal women in the US. Using a US national probability sample of 868 postmenopausal women aged 57 to 85 years, epithelial maturation value (MV) generated from self-collected vaginal specimens were calculated and the findings compared with historical clinical data. Researchers found:
- In every age group, vaginal estrogenization was higher among postmenopausal nonusers of HT in the 2005-2006 US cohort than reported for the 1960s Canadian clinical cohort.
- MV was also higher among women who used postmenopausal hormone therapy (HT) in the prior 12 months vs those who did not.
- The strongest independent correlates were current HT use, obesity, and African American race.
- Half of all women exhibit low vaginal estrogenization postmenopause.
Lindau ST, Dude A, Gavrilova N, Hoffmann JN, Schumm PL, McClintock MK. Prevalence and correlates of vaginal estrogenization in postmenopausal women in the United States. [Published online ahead of print November 28, 2016]. Menopause. doi:10.1097/GME.0000000000000787.
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