Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Uric Acid and CED in Postmenopausal Women

Hypertension; ePub 2016 Dec 19; Prasad, et al

In postmenopausal women, serum uric acid (SUA) levels are associated with coronary endothelial dysfunction (CED) and may also be related to inflammation, a recent study found. In this prospective cohort study SUA, high-sensitivity C-reactive protein levels, and neutrophil count were measured in 229 postmenopausal women (median age 58 years) who underwent diagnostic catheterization. Researchers found:

  • CED was diagnosed in 59% of postmenopausal women.
  • Mean uric acid level was 4.7±1.3 mg/dL.
  • Postmenopausal women with CED had significantly higher SUA compared with patients without CED.
  • There was a significant correlation between SUA and percent change in coronary blood flow to acetylcholine.
  • SUA levels were significantly associated with increased neutrophil count and high-sensitivity C-reactive protein levels among patients with CED.

Citation:

Prasad M, Matteson EL, Herrmann J, et al. Uric acid is associated with inflammation, coronary microvascular dysfunction, and adverse outcomes in postmenopausal women. [Published online ahead of print December 19, 2016]. Hypertension. doi:10.1161/HYPERTENSIONAHA.116.08436.