Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Trends in Estrogen Use Among US Women

Menopause; ePub 2017 Dec 28; Weissfeld, et al

Among US postmenopausal women, the use of oral estrogen generally and vaginally administered estrogen products declined in age groups <65 years between 2006 and 2015, a recent study found. Researchers used prescription claims for US commercial health insurance to calculate, in women aged ≥50 years (n=12,007,364), the age-standardized and age-specific annual prevalence of estrogen use by formulation and route of administration during the specified study period. They found:

  • The age-standardized annual prevalence of a prescription claim for oral estrogens declined over time, from 83 per 1,000 women in 2007 to 42 per 1,000 women in 2015.
  • The age-standardized annual prevalence of a prescription claim for vaginal estrogens peaked in 2011, at 42 per 1,000 women, before declining to 35 per 1,000 women in 2015.
  • The age-standardized annual prevalence of a prescription claim for transdermal estrogen fluctuated between 15 and 17 per 1,000 women.
  • Annual prevalence rates for vaginal rings and inserts declined over the latter half of the study period in age groups <65 years.


Weissfeld JL, Liu W, Woods C, et al. Trends in oral and vaginally administered estrogen use among US women 50 years of age or older with commercial health insurance. [Published online ahead of print December 28, 2017]. Menopause. doi:10.1097/GME.0000000000001054.

This Week's Must Reads

Management of Early Pregnancy Loss, Obstet Gynecol; ePub 2018 Nov; ACOG

Opioid Use After Laparoscopic Hysterectomy, Am J Obstet Gynecol; ePub 2018 Oct 25; Wong, et al

Combined Gynecologic Ca & Pelvic Floor Dysfunction Surgery, Female Pelvic Med Reconstr Surg; ePub 2018 Oct 22; McConnell, et al

Progestogen for Prevention of Recurrent Miscarriage, Cochrane Database; ePub 2018 Oct 8; Haas, et al

Delayed Pushing & Spontaneous Vaginal Delivery , JAMA; 2018 Oct 9; Cahill, Srinivas, et al

Must Reads in Menopause

Cardiac Autonomic Function in Midlife Women, Menopause; ePub 2018 Jun 18; Fu, et al

Vasomotor Symptoms in Older Women, Menopause; ePub 2018 May 7; David, et al

Estrogen-alone Therapy & Invasive Breast Cancer, Menopause; ePub 2018 May 7; Shufelt, et al

Vascular Dysfunction During Menopausal Transition, Menopause; ePub 2018 Apr 9; Hildreth, et al

Menopausal HT & Hyperkyphosis Prevention , Menopause; ePub 2018 Feb 16; Woods, et al