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Surgical Menopause and CV Risk Factors

Are antecedent young-adult levels predictors?

Hysterectomy was not associated with risk factors for cardiovascular disease (CVD); however, antecedent young-adult levels of CVD risk factors were strong predictors of levels of postmenopausal risk factors. This according to a study of women aged 18 to 30 years that compared changes in risk factors for CVD before and after natural menopause (NM), hysterectomy with at least 1 ovary conserved (HOC), or hysterectomy with bilateral oophorectomy (HBSO). Researchers found:

• During 25 years follow-up, 1,045 women reached menopause (NM, n=588; for HOC, n=304; and for HBSO, n=153).

• There was a small increase in rate of change for high-density lipoprotein cholesterol and a decrease for triglycerides.

• Hysterectomy was not associated with risk factors for CVD after accounting for baseline values.

• Antecedent young-adult levels of CVD risk factors were strong predictors of levels of postmenopausal risk factors.

Citation: Appiah D, Schreiner PJ, Bower JK, Sternfeld B, Lewis CE, Wellons MF. Is surgical menopause associated with future levels of cardiovascular risk factor independent of antecedent levels? The CARDIA Study. [Published online ahead of print December 1, 2015]. Am J Epidemiol. doi: 10.1093/aje/kwv162.