Clinical Edge

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Stress & Fatigue During Menopausal Transition

Menopause; ePub 2017 Nov 20; Taylor-Swanson, et al

Coupling relationships of stress on fatigue show evidence for shifts in regulatory relationships with one another across the menopausal transition (MT), a recent study found. The study evaluated the regulatory dynamics between stress and fatigue experienced by women during the MT and early postmenopause (EPM). Participants were from the longitudinal Seattle Midlife Women’s Health Study with eligible women (n=56) completing questionnaires on ≥60 occasions. The total number of observations across the sample was 4,224. Women were staged in either late reproductive, early or late transition, or EPM stage. Researchers found:

  • Eligible women (median age 35 years) were well educated, employed, married or partnered, and white.
  • Fit indices suggested the model depicts the relationships of stress and fatigue.
  • A loss in model fit across stages suggests that the 4 stages differed in their dynamics.
  • All stages showed fixed-point attractor dynamics: fatigue became less stable over time, and stress generally became more stable over time.


Taylor-Swanson L, Wong AE, Pincus D, et al. The dynamics of stress and fatigue across menopause: Attractors, coupling, and resilience. [Published online ahead of print November 20, 2017]. Menopause. doi:10.1097/GME.0000000000001025.