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Reproductive History & Risk of T2D in Postmenopausal Women

Menopause; ePub 2016 Jul 25; LeBlanc, Kapphahn, et al

Reproductive history may play a role in the development of type 2 diabetes (T2D) in women, and women with shorter and longer reproductive periods may benefit from lifestyle counseling as a measure of prevention. This according to findings from the Women’s Health Initiative and a cohort analysis of 124,379 postmenopausal women aged 50 to 79 years. Researchers found:

• Women with the shortest (<30 years) reproductive periods had a 37% greater risk of developing T2D than women with medium-length reproductive periods (36 to 40 years).

• Women with the longest (≥45 years) reproductive periods had a 23% higher risk than women with medium-length periods.

• Women with a final menstrual period before age 45 and after age 55 had an increased risk of diabetes (HR, 1.04) vs women with age of final menstrual period between age 46 and 55 years.

Citation: LeBlanc ES, Kapphahn K, Hedin H, et al. Reproductive history and risk of type 2 diabetes mellitus in postmenopausal women: Findings from the Women’s Health Initiative. [Published online ahead of print July 25, 2016]. Menopause. doi:10.1097/GME.0000000000000714.