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Pregnancy in Advanced Age and Risk of CV Events

Am J Obstet Gynecol; ePub 2016 Dec 9; Qureshi, et al

A higher risk for hemorrhagic stroke in postmenopausal period was observed among women with pregnancy in advanced age, a recent study found. Researchers analyzed data for 72,221 women aged 50 to 79 years in the Women’s Health Initiative study to determine the effect of pregnancy in advanced age (last pregnancy at age ≥40 years) on risk of ischemic stroke, hemorrhagic stroke, myocardial infarction (MI), and cardiovascular (CV) death over a mean period of 12±1 years. They found:

  • 3,306 (4.6%) participants reported pregnancy in advanced age.
  • Compared with pregnancy in normal age, the rates of ischemic stroke (2.4% vs 3.8%), hemorrhagic stroke (0.5% vs 1.0%), and CV death (2.3% vs 3.9%) were significantly higher among women with pregnancy in advanced age.
  • Women with pregnancy in advanced age were 50% more likely to experience a hemorrhagic stroke (HR, 1.5).
  • There was no significant difference in the risk of ischemic stroke, MI, and CV death among women with pregnancy in advanced age after adjusting for potential confounders.


Qureshi AI, Saeed O, Malik AA, Suri FK. Pregnancy in advanced age and the risk of stroke in postmenopausal women. Analysis of Women’s Health Initiative study. [Published online ahead of print December 9, 2016]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2016.12.004.