Clinical Edge

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Menopause and Risk of Fracture

Effects at varying ages

Younger age at menopause may be a risk factor contributing to decreased bone mineral density (BMD) and increased fracture risk in healthy postmenopausal women, according to a comparison of hazard ratios for fractures and differences in BMD among 21,711 postmenopausal women. Study highlights included:

• No differences in absolute fracture risk were found among menopause age groups before multivariable adjustments.

• Women who underwent menopause before aged 40 years had a higher fracture risk at any site compared with women who underwent menopause at age 50 years or older (HR 1.21) after multivariable adjustments.

• In a subset with BMD measurements (n=1,351), whole-body BMD was lower in women who reported menopause before age 40 years than in women who reported menopause at ages 40 to 49 years and at age 50 years or older.

Citation: Sullivan SD, Lehman A, Fridtjof T, et al. Effects of self-reported age at nonsurgical menopause on time to first fracture and bone mineral density in the Women’s Health Initiative Observational Study. Menopause. 2015;22(10):1035-1044. doi: 10.1097/GME.0000000000000451.