Clinical Edge

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Menopausal Symptoms & CVD Mortality

Menopause; ePub 2016 Sep 26; Thurston, et al

Higher cardiovascular disease (CVD) mortality and reduced endothelial function was observed in women with signs and symptoms of ischemia who had vasomotor symptoms (VMS) beginning early in midlife compared to women with later onset symptoms, a recent study found. The Women’s Ischemia Syndrome Evaluation enrolled 254 postmenopausal women aged >50 years with both ovaries, not taking hormone therapy, and referred for coronary angiography for suspected myocardial ischemia. Researchers found:

  • Women reporting early onset VMS (HR, 3.35) and women who never had VMS (HR, 2.17) had higher CVD mortality compared to women with later onset symptoms.
  • Women with early onset VMS also had lower flow-mediated dilation (FMD) vs women with later onset symptoms.


Thurston RC, Johnson BD, Shufelt CL, et al. Menopausal symptoms and cardiovascular disease mortality in the Women’s Ischemia Syndrome Evaluation (WISE). [Published online ahead of print September 26, 2016]. Menopause. doi:10.1097/GME.0000000000000731.