Clinical Edge

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Menopausal HT & Hyperkyphosis Prevention

Menopause; ePub 2018 Feb 16; Woods, et al

Women reporting continuous or remote past hormone therapy (HT) use had less pronounced kyphosis than never-users by their mid-80s, suggesting a possible role for HT in the prevention of age-related hyperkyphosis. Researchers evaluated the cross-sectional association between Cobb angle of kyphosis from lateral spine radiographs and pattern of self-reported HT use during the prior 15-year period in 1,063 women (mean age 83.7±3.3 years; mean Cobb angle of 51.3±14.6°) from the Study of Osteoporotic Fractures. They found:

  • 46% of women were characterized as never-users of HT, 24% as remote past users, 17% as intermittent users, and 12% as continuous users.
  • In minimally adjusted models, the mean Cobb angle was 4.0° less in continuous HT users vs never-users; this association was attenuated to 2.8° in fully adjusted models.
  • Remote past HT users had 3.0° less kyphosis compared with never-users in minimally adjusted models; attenuated to 2.8° less in fully adjusted models.
  • Intermittent users did not differ from never-users in degree of kyphosis.


Woods GN, Huang M-H, Cawthon PM, et al. Patterns of menopausal hormone therapy use and hyperkyphosis in older women. [Published online ahead of print February 16, 2018]. Menopause. doi:10.1097/GME.0000000000001070.