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Link Between Migraine & Risk of CVD in Women?

BMJ; ePub 2016 May 31; Kurth, Winter, et al

There is a consistent link between migraine and cardiovascular disease (CVD) events in women, including cardiovascular mortality, and women with migraine should be evaluated for further risk. This according to a large cohort study of 115,541 women aged 25 to 42 years at baseline, free of angina and CVD, and followed for more than 20 years. Researchers found:

• 17,531 (15.2%) women reported a physician’s diagnosis of migraine.

• 1,329 major CVD events occurred over 20 years of follow-up and 223 women died from CVD.

• Migraine was associated with an increased risk for major CVD (HR=1.50), myocardial infarction (HR=1.39), stroke (HR=1.62), and angina/coronary revascularization procedures (HR=1.73), compared to women without migraine.

• Migraine was also associated with a significantly increased risk for CVD mortality (HR=1.37).

• Associations were similar across subgroups of women, including by age, smoking status, hypertension, postmenopausal hormone therapy, and oral contraceptive use.

Citation: Kurth T, Winter AC, Eliassen AH, et al. Migraine and risk of cardiovascular disease in women: Prospective cohort study. [Published online ahead of print May 31, 2016]. BMJ. doi:http://dx.doi.org/10.1136/bmj.i2610.