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Incident Heart Failure and Age at Menopause

J Am Heart Assoc; ePub 2016 Jul 28; Appiah, et al

There is a modestly greater risk of heart failure (HF) among women who experience menopause at an early age, according to a recent study and meta-analysis. The Atherosclerosis Risk in Communities (ARIC) study included 5,629 postmenopausal women (mean age 56 years, 26% with bilateral oophorectomy) without HF. Researchers found:

  • 965 incident HF events occurred during median follow-up of 21.4 years.
  • Hazard ratios for incident HF across categories of age at menopause (≤45 years, 45 to 49 years, 50 to 54 years, and >55 years) were 1.32, 1.17, 1.00 (referent), and 1.12, respectively.
  • Women with early menopause had elevated HF risk (HR, 1.20) compared with women with later onset of menopause (aged ≥45 years).
  • Results were similar in meta-analysis (3,568 events) in 3 studies (HR, 1.33).


Appiah D, Schreiner PJ, Demerath EW, Loehr LR, Chang PP, Folsom AR. Association of age at menopause with incident heart failure: A prospective cohort study and meta-analysis. [Published online ahead of print July 28, 2016]. J Am Heart Assoc. doi:10.1161/JAHA.116.003769.