Clinical Edge

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Hormone Therapy Effect in Pelvic Organ Prolapse

Menopause; ePub 2017 May 22; Wasenda, et al

Hormone therapy (HT) may have a minor negative effect of pelvic organ support; however, this effect is likely too small to be clinically relevant, a recent study concluded. The retrospective observational study included 1,443 postmenopausal women with pelvic floor dysfunction attending a tertiary urogynecology center between January 2012 and March 2015. Researchers found:

  • Current HT was significantly associated with sonographically determined descent of the rectal ampulla and Gh + Pb.
  • Past HT use, duration of HT use, or current vaginal estrogen use was not associated with pelvic organ support.
  • On multivariate analysis, the association between current HT and Gh + Pb as well as increased descent of the rectal ampulla on ultrasound remained significant.


Wasenda EJ, Kamisan IA, Subramaniam N, Dietz PH. Pelvic organ prolapse: Does hormone therapy use matter? [Published online ahead of print May 22, 2017]. Menopause. doi:10.1097/GME.0000000000000898.