Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Chronic Disease Risk with Vaginal Estrogen Use

Menopause; ePub 2018 Dec 17; Bhupathiraju, et al

Among a cohort of postmenopausal women, vaginal estrogen use was not associated with a higher risk of cardiovascular disease (CVD) or cancer, according to a recent study. Participants from the Nurses’ Health Study (1982-2012) were not users of systemic hormone therapy at the start of the study or during follow-up. Vaginal estrogen use was self-reported on the biennial questionnaires. Researchers found:

  • Over 18 years of follow-up and after adjusting for covariates, risk for CVD, cancer, and hip fracture were not different between users and nonusers of vaginal estrogen.
  • No statistically significant increase in risk of any health outcome was observed with vaginal estrogen use.
  • The stratified results were generally similar to those for the total cohort when researchers examined associations by hysterectomy status in sensitivity analysis.


Bhupathiraju SN, Grodstein F, Stampfer MJ, et al. Vaginal estrogen use and chronic disease risk in the Nurses’ Health Study. [Published online ahead of print December 17, 2018]. Menopause. doi:10.1097/GME.0000000000001284.

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