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Chronic Disease Risk with Vaginal Estrogen Use

Menopause; ePub 2018 Dec 17; Bhupathiraju, et al

Among a cohort of postmenopausal women, vaginal estrogen use was not associated with a higher risk of cardiovascular disease (CVD) or cancer, according to a recent study. Participants from the Nurses’ Health Study (1982-2012) were not users of systemic hormone therapy at the start of the study or during follow-up. Vaginal estrogen use was self-reported on the biennial questionnaires. Researchers found:

  • Over 18 years of follow-up and after adjusting for covariates, risk for CVD, cancer, and hip fracture were not different between users and nonusers of vaginal estrogen.
  • No statistically significant increase in risk of any health outcome was observed with vaginal estrogen use.
  • The stratified results were generally similar to those for the total cohort when researchers examined associations by hysterectomy status in sensitivity analysis.

Citation:

Bhupathiraju SN, Grodstein F, Stampfer MJ, et al. Vaginal estrogen use and chronic disease risk in the Nurses’ Health Study. [Published online ahead of print December 17, 2018]. Menopause. doi:10.1097/GME.0000000000001284.