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Tubal Factor Infertility & Chlamydia Association

Am J Obstet Gynecol; ePub 2017 May 19; Gorwitz, et al

Low population attributable fraction estimates suggest factors in addition to chlamydia contribute to tubal factor infertility in a study of infertile women. The case-control study, which estimated the population attributable fraction of tubal infertility associated with Chlamydia trachomatis infection by race, enrolled infertile women from October 2012 to June 2015. Tubal factor infertility case status was primarily defined by unilateral or bilateral fallopian tube occlusion (cases) or bilateral fallopian tube patency (controls) on hysterosalpingogram. Researchers found:

  • 107 black women and 620 white women were enrolled in the study.
  • C. trachomatis seropositivity by either assay was 81% among black and 31% among non-black participants.
  • No significant association was detected between chlamydia and tubal factor infertility among blacks or non-blacks, and the estimated population attributable fraction was 15% among blacks and 11% among non-blacks.
  • However, use of alternate serologic measures and tubal factor infertility definitions impacted the magnitude of the chlamydia-tubal factor infertility association, resulting in a significant association among non-blacks.


Gorwitz RJ, Wiesenfeld HC, Chen PL, et al. Population attributable fraction of tubal factor infertility associated with chlamydia. [Published online ahead of print May 19, 2017]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2017.05.026.