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Prior Hysterectomy and BSO in Postmenopausal Women

What is the venous thrombosis risk?

The risk of venous thrombosis (VT) among postmenopausal women was not impacted substantially by prior hysterectomy, with or without bilateral salpingo-oophorectomy (BSO). This according to a study of incident VT cases (n=1,623) and matched controls that had not experienced a prior VT (n=4,480). Researchers found:

• There was no greater VT risk in women with prior hysterectomy without BSO, whether they were (aOR=0.80) or were not (aOR=1.09) using hormone therapy (HT), compared to women with an intact uterus who were not using HT.

• Women with prior hysterectomy and BSO who were using HT were not at greater VT risk (OR=1.00), but there was evidence of a 25% greater risk associated with prior hysterectomy with BSO and no current HT use.

Citation: Harrington LB, Weiss NS, Wiggins KL, et al. Prior hysterectomy and oophorectomy and incident venous thrombosis risk among postmenopausal women: a population-based, case-control study. [Published online ahead of print January 6, 2016]. Menopause. doi: 10.1097/GME.0000000000000591.