Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Primary Debulking Surgery for Advanced Ovarian Ca

Refining a risk-prediction model

Age, ASA score, preoperative albumin, FIGO stage, surgical complexity, and body mass index all influence morbidity and mortality after primary debulking surgery (PDS) and are important factors in refining a prediction model for complications after PDS for advanced epithelial ovarian cancer (EOC), according to a study of 620 patients. The study determined:

• 22.3% of study participants who underwent PDS experienced a grade ≥3 complication.

• Within 90 days of surgery, 8.9% of patients died.

• Multivariable model included age (OR=1.76), ASA score ≥3 (OR=3.28), preoperative albumin <3.5 (OR=4.31), and BMI (OR=2.04) was predictive of 90-day mortality.

Citation: Kumar A, Janco JM, Mariani A, et al. Risk-prediction model of severe postoperative complications after primary debulking surgery for advanced ovarian cancer. [Published online ahead of print November 2, 2015]. Gynecol Oncol. doi: 10.1016/j.ygyno.2015.10.025.