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Preoperative Thrombocytosis and Leukocytosis

Is there an increase in postoperative mortality?

Patients with ovarian cancer who presented with preoperative thrombocytosis and/or leukocytosis were identified as having an increased risk of major postoperative complication, and those with both thrombocytosis and leukocytosis experienced twice the rate of major complication and a four-fold increase in postoperative death, according to a study of 1,072 patients. Researchers found:

• Leukocytosis was associated with major complication (16.5% vs 10.3%) but not postoperative death (3.0% vs. 1.3%).

• Thrombocytosis was associated with major complication (19.4% vs 10.7%) but not postoperative death (2.9% vs 1.5%).

• Patients with both thrombocytosis and leukocytosis had increased rates of both major complication (22.6% vs 10.9%) and mortality (5.7% vs 1.4%).

Citation: Barber EL, Boggess JF, Van Le L, et al. Association of preoperative thrombocytosis and leukocytosis with postoperative morbidity and mortality among patients with ovarian cancer. [Published online ahead of print November 5, 2015]. Obstet Gynecol. doi: 10.1097/AOG.0000000000001138.