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Placental Infection in Late Preterm Infants

Role of Ureaplasma species explored

The presence of Ureaplasma species were prevalent in the placentae of women delivering moderate/late preterm and was associated with histological chorioamnionitis. This according to a study in which women delivering moderate/late preterm (n=477) and their infants/placentae (n=535) were recruited and swabs of chorioamnion tissue, chorioamnion tissue and cord blood were obtained at delivery and analyzed. Researchers found:

• Microorganisms were detected in 10.6% of all placentae, delivered late preterm (n=443) and at term (n=92).

• Significantly, Ureaplasma spp. were the most prevalent microorganisms detected and their presence was associated with histological chorioamnionitis in moderate/late preterm and term placentae.

• The presence of ureaplasmas within the chorioamnion was also associated with elevated levels of granulocyte colony-stimulating factor.

Citation: Sweeney EL, Kallapur SG, Gisslen T, et al. Placental infection with Ureaplasma species is associated with histologic chorioamnionitis and adverse outcomes in moderate to late preterm infants. [Published online ahead of print December 15, 2015]. J Infect Dis. doi: 10.1093/infdis/jiv587.