In patients with epithelial ovarian cancer (EOC), the use of oral contraceptives may have lasting effects on tumor characteristics, and potentially favorable prognosis on overall survival, according to a cohort study of 387 women with newly diagnosed EOC, fallopian tube, and primary peritoneal cancers. The study concluded:
• Decreased risk of death was observed in women who reported prior use of OC (aHR=0.79), previous pregnancy (aHR=0.77), or a live birth (aHR=0.81) after adjusting for age at diagnosis, stage and histologic subtype.
• OC use was associated with a crude reduced risk of death (HR=0.55) with reported median overall survival of 81 months in OC users vs. 46 months in nonusers.
• Patients who reported a single live birth experienced the largest potential survival advantage (aHR=0.61).
• OC use and prior pregnancy were associated with improved survival across all strata.
Citation: Kolomeyevskaya NV, Szender JB, Zirpoli G, et al. Oral contraceptive use and reproductive characteristics affect survival in patients with epithelial ovarian cancer: A cohort study. Int J Gynecol Cancer. [Published online ahead of print August 13, 2015]. doi: 10.1097/IGC.0000000000000540.
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