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Choosing a Prophylactic Antibiotic

Risk of surgical site infection after hysterectomy

A higher risk of surgical site infection after hysterectomy was observed among women receiving a recommended β-lactam alternative or nonstandard regimen compared with those receiving β-lactam antibiotic regimens. This according to a study and analysis of 21,358 hysterectomies. Researchers found:

• Overall rate of “any surgical site infection” was 2.06%.

• Adjusted rates of “any surgical site infection” were 1.8%, 3.1%, and 3.7% for β-lactam, β-lactam alternatives, and nonstandard groups, respectively.

• Compared with the β-lactam antibiotics, the risk of “any surgical site infection” was higher for the group receiving β-lactam alternatives (OR=1.7) or the nonstandard antibiotics (OR=2.0).

Citation: Uppal S, Harris J, Al-Niaimi A, et al. Prophylactic antibiotic choice and risk of surgical site infection after hysterectomy. [Published online ahead of print January 7, 2016]. Obstet Gynecol. doi: 10.1097/AOG.0000000000001245.