Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Can HPV Self-Testing Increase Screening Rates?

Sex Transm Dis; ePub 2017 Jul 24; Smith, et al

Human papillomavirus (HPV) self-testing has the potential to reach a broad segment of infrequently screened women in the US, a recent study found. To assess this intervention among high-risk women in the US that included self-testing through population-based recruitment, mailed kit delivery and return by mail, and results delivery to telephone, 429 women without a Papanicolaou (Pap) test in 4 or more years were recruited from the general population. Participants aged 30 to 65 years were mailed a kit to self-collect a cervicovaginal sample at home, return the sample by mail, and receive HPV results by telephone, with referral to follow-up cytological Pap testing at a local clinic. Researchers found:

  • ~Two-thirds of participants returned a self-collected sample; 15% tested HPV DNA positive.
  • Women with HPV self-test-positive results reported higher rates of follow-up PAP tests compared to those with self-test negative results (82% vs 51%).
  • No demographic differences were found in self-test return rate of HPV positivity.
  • Most women had “mostly positive” overall thoughts about the self-test.


Smith J, Des Marais AC, Deal AM, et al. Mailed human papillomavirus self-collection with Papanicolaou test referral for infrequency screened women in the United States. [Published online ahead of print July 24, 2017]. Sex Transm Dis. doi:10.1097/OLQ.0000000000000681.

This Week's Must Reads

Prophylactic Antibiotic Use in Labor & Delivery, Obstet Gynecol; 2018 Sep; Coleman, et al

USPSTF on Screening for Cervical Cancer, JAMA; 2018 Aug 21; US Preventive Services Task Force

Prevention of Obstetric Lacerations at Vaginal Delivery, Obstet Gynecol; 2018 Sep; Cichowski, et al

Effect of Menstrual Bleeding on IUD Discontinuation, Am J Obstet Gynecol; ePub 2018 Aug 28; Hobby, et al

Leukemia risk after maternal contraception use, Hargreave M et al. Lancet Oncol. 2018 Sep 6. doi: 10.1016/S1470-2045(18)30479-0

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Uterine Weight & Complications After Hysterectomy, Am J Obstet Gynecol; ePub 2018 Jun 27; Louie, et al

New Persistent Opioid Use After Hysterectomy, Am J Obstet Gynecol; ePub 2018 Jun 18; Swenson, et al

Infection Prevention After Gynecologic Procedures, Obstet Gynecol; ePub 2018 Jun; Soper, Chelmow, et al

Treatment Update for Polycystic Ovary Syndrome, Obstet Gynecol; ePub 2018 Jun; Legro, et al

Hysterectomy Performed by Very Low-Volume Surgeons, Obstet Gynecol; ePub 2018 May 7; Ruiz, et al