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Are Depressive Symptoms Stable During Menopause?

Menopause; ePub 2016 Aug 22; Hickey, et al

While most women display stable depressive symptoms during the menopause transition, approximately 9% have increasing symptoms and a similar proportion has decreasing symptoms, a recent study found. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression scale (CESD-10). Researchers found:

  • Women with increasing depressive symptoms were more likely to have had bilateral salpingo-oophorectomy or be perimenopausal at baseline vs women in the stable low group.
  • Depressive symptoms were higher in perimenopausal women, after hysterectomy alone, bilateral salpingo-oophorectomy with or without hysterectomy, hormone therapy users, and after starting or stopping hormone therapy compared with postmenopausal women.
  • These depressive symptoms were associated with oophorectomy and stopping or starting hormone therapy.


Hickey M, Schoenaker DA, Joffe H, Mishra GD. Depressive symptoms across the menopause transition: findings from a large population-based cohort study. [Published online ahead of print August 22, 2016]. Menopause. doi:10.1097/GME.0000000000000712.