Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Survival in Women with Early-Stage Uterine Cancer

Gynecol Oncol; ePub 2016 Oct 9; Fader, et al

Women with early-stage uterine serous (USC) and carcinosarcoma (CS) have poor survival when compared to women with grade 3 endometrioid adenocarcinoma (ENDO), a recent study found. This post-hoc analysis analyzed the clinicopathologic features, recurrence patterns, and survival outcomes of women with high-grade uterine cancer (UC) enrolled in the Gynecologic Oncology Group LAP2 trial. Researchers found:

  • Of the 2,600 enrolled patients in LAP2, 753 had high-grade UC, 350 had ENDO, 289 had USC, 42 had CC, and 72 had CS.
  • With a median follow-up of 60 months, those with USC, CC, and CS subtypes had higher recurrence rates, extra-pelvic recurrences, and poorer progression-free survival (PFS) and overall survival (OS) compared to patients with ENDO.
  • Patterns of recurrence and survival were not different in those staged with LSC vs LAP.
  • Survival was similar for high-grade uterine cancer patients staged via laparoscopy.

Citation:

Fader AN, Java J, Tenney M, et al. Impact of histology and surgical approach on survival among women with early-stage, high-grade uterine cancer: An NRG Oncology/Gynecologic Oncology Group ancillary analysis. [Published online ahead of print October 9, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.10.016.