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Preoperative Hyponatremia in Women with Ovarian Cancer

Gynecol Oncol; ePub 2016 Jul 4; Martin, Goff, et al

Postoperative 30-day mortality and morbidity was observed in women with ovarian, fallopian tube (FT), and primary peritoneal cancers (PPC) and diagnosed with hyponatremia. This according to a retrospective, population-based study of 4,009 women with a postoperative diagnosis of ovarian, FT, or PPC who had a cytoreductive procedure in the National Surgical Quality Improvement Program (NSQIP) database from 2005 to 2013. Researchers found:

• 30-day mortality was higher in the hyponatremic group (≤134 mEq/L) vs the normal serum sodium group (135 mEq/L to 142 mEq/L), (3.56% vs 1.18%).

• There was an increased risk of postoperative complications for patients aged >65 years with diagnosis of at least 2 pertinent preoperative lab abnormalities, including hyponatremia.

• Preoperative hyponatremia was associated with an increased risk of hospital stay of >14 days (adjusted OR, 1.69) and 30-day postoperative mortality (aOR, 2.37), after adjusting for serum albumin and other confounders.

Citation: Martin JY, Goff BA, Urban RR. Preoperative hyponatremia in women with ovarian cancer: An additional cause for concern? [Published online ahead of print July 4, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.06.018.