Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Pelvic Lymphadenectomy & Use of Adjuvant Radiotherapy

Gynecol Oncol; ePub 2016 Dec 22; Matsuo, et al

A significant increase in intracavitary brachytherapy (ICBT) use and decrease in whole pelvic radiotherapy (WPRT) was observed among women with early-stage endometrial cancer, a recent study found. The Surveillance, Epidemiology, and End Results Program was used to identify surgically treated stage I-II endometrial cancer between 1983 and 2012 (type 1, n=79,474; type 2, n=25,020). Researchers found:

  • ICBT use exceeded WPRT use in 2003 for type 1 stage IA, and in 2007 for type 1 stage IB and type 2 stage IA diseases.
  • The number of sampled pelvic nodes significantly increased over time in type 1-2 stage I-II diseases.
  • On multivariable analysis, the extent of sampled pelvic nodes was significantly associated with ICBT use for type 1 cancer.

The authors concluded that the results suggest that surgeons and radiation oncologists are evaluating the extent of pelvic lymphadenectomy when counseling women with early-stage endometrial cancer for adjuvant radiotherapy.

Citation:

Matsuo K, Machida H, Ragab OM, Takiuchi T, Pham HQ, Roman LD. Extent of pelvic lymphadenectomy and use of adjuvant vaginal brachytherapy for early-stage endometrial cancer. [Published online ahead of print December 22, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.12.012.