Overall survival (OS) and decreased all-cause mortality, including death resulting from cardiovascular disease (CVD) and other chronic diseases, was observed among young women with stage IA cervical cancer who underwent ovarian conservation at hysterectomy, a recent study found. This retrospective study identified 16,511 hysterectomy-based surgically treated patients with stage I cervical cancer diagnosed between 1983 and 2012. Researchers found:
- Among 5,526 women aged <50 years with stage IA disease who underwent hysterectomy without radiotherapy, OS was significantly higher in patients undergoing ovarian conservation than in those undergoing oophorectomy; cervical cancer-specific survival was similar between the groups.
- On multivariable analysis, ovarian conservation remained an independent prognostic factor for improved OS and was independently associated with lower cumulative risks of death from CVD and other chronic disease compared to oophorectomy.
- Among 3,893 women aged <50 years with stage IB disease who underwent hysterectomy without radiotherapy, results among the ovarian conservation group and oophorectomy group were similar.
Matsuo K, Machida H, Shoupe D, et al. Ovarian conservation and overall survival in young women with early-stage cervical cancer. [Published online ahead of print December 2, 2016]. Obstet Gynecol. doi:10.1097/AOG.0000000000001754.
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Maternal Factors in Cervical Cancer Prevention, Womens Health Issues; ePub 2019 Jan 10; Charlton, et al
Combined Gynecologic Ca & Pelvic Floor Dysfunction Surgery, Female Pelvic Med Reconstr Surg; ePub 2018 Oct 22; McConnell, et al