Clinical Edge

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Nonalcoholic Fatty Liver Disease

Does surgical staging heighten risk?

The risk of developing nonalcoholic fatty liver disease (NAFLD) significantly increased in young women with endometrial cancer who underwent surgical staging with or without oophorectomy, according to a study of 875 women with endometrial tumor. The study included 712 oophorectomy cases and 163 nonoophorectomy cases and found:

• The prevalence of NAFLD in the study’s 875 women with endometrial tumor was 14.1%, 20.5%, and 38.4% at 1, 2 and 5 years after surgical operation.

• Age younger than 40 years and 40 to 49 years were predictors for developing NAFLD after surgical operation compared to ages 50 and older.

• NAFLD was significantly associated with postoperative development of diabetes and hypercholesterolemia.

Citation: Matsuo K, Gualtieri MR, Cahoon SS, et al. Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer. Menopause. [Published online ahead of print July 13, 2015]. doi: 10.1097/GME.0000000000000500.