The risk of developing nonalcoholic fatty liver disease (NAFLD) significantly increased in young women with endometrial cancer who underwent surgical staging with or without oophorectomy, according to a study of 875 women with endometrial tumor. The study included 712 oophorectomy cases and 163 nonoophorectomy cases and found:
• The prevalence of NAFLD in the study’s 875 women with endometrial tumor was 14.1%, 20.5%, and 38.4% at 1, 2 and 5 years after surgical operation.
• Age younger than 40 years and 40 to 49 years were predictors for developing NAFLD after surgical operation compared to ages 50 and older.
• NAFLD was significantly associated with postoperative development of diabetes and hypercholesterolemia.
Citation: Matsuo K, Gualtieri MR, Cahoon SS, et al. Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer. Menopause. [Published online ahead of print July 13, 2015]. doi: 10.1097/GME.0000000000000500.
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