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Hypoalbuminemia & SSI in Patients with Vulvar Cancer

Gynecol Oncol; ePub 2016 Jul 6; Sullivan, et al

Major postoperative wound complications in women undergoing surgery for vulvar cancer were observed in patients with low preoperative albumin, a recent study found. The study included 777 vulvar cancer patients (mean age 66, median BMI 28.9 kg/m2) undergoing vulvectomy with or without lymphadenectomy (LND) from 2008 to 2013. Primary outcome was major wound complication and secondary outcome was minor wound complication. Researchers found:

• 514 (66.2%) patients had vulvar surgery alone and 263 (30.3%) had an LND.

• Incidence of wound complication was 10.4% with 48 minor and 39 major complications.

• There was no difference in major wound complications when a LND was performed.

• Preoperative albumin was recorded in 429 (55.2%) patients.

• Patients with hypoalbuminemia were more likely to have a major wound complication (OR, 2.9), even after adjusting for BMI, age, preoperative hematocrit, and diabetes (aOR, 2.7)

• Patients with a wound infection had 10 times the odds of being readmitted within 30 days (OR, 9.5).

Citation: Sullivan SA, Van Le L, Liberty AL, Soper JT, Barber EL. Association between hypoalbuminemia and surgical site infection in vulvar cancers. [Published online ahead of print July 6, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.06.021.