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HIV and Survival in Women with Cervical Cancer

J Clin Oncol; ePub 2016 Aug 29; Dryden-Peterson, et al

HIV infection significantly decreases cervical cancer survival, even with the use of antiretroviral treatment, a recent study found. A total of 348 women with cervical cancer were enrolled in the study from 2010 to 2015, including 231 (66.4%) with HIV and 96 (27.6%) without HIV. The majority of the study population (81.8%) with HIV received antiretroviral therapy before cancer diagnosis. Researchers found:

  • After median follow-up of 19.7 months, 117 (50.7%) women with HIV and 40 (41.7%) without HIV died.
  • 3-year survival for women with HIV was 35%, and 48% for those without HIV.
  • In adjusted analysis, HIV infection significantly increased the risk for death among all women (HR, 1.95) and in the subset that received guideline-concordant treatment (HR, 2.63).
  • Women with a more-limited stage cancer, those treated with curative intent, and those with a lower CD4 cell count showed a greater adverse effect of HIV on survival.

Citation:

Dryden-Peterson S, Bvochora-Nsingo M, Sueja G, et al. HIV infection and survival among women with cervical cancer. [Published online ahead of print August 29, 2016]. J Clin Oncol. doi:10.1200/JCO.2016.67.9613.