Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Health-Related QoL in Women with Ovarian Cancer

Gynecol Oncol; ePub 2016 Dec 14; Doll, et al

Pre-diagnosis of health-related quality of life (HRQOL) was predictive of receiving surgery, but not of overall survival (OS), in older women with advanced epithelial ovarian cancer, a recent study found. The Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) database was queried to identify 374 women aged ≥65 years with advanced stage epithelial ovarian cancer from 1998 to 2011. Researchers found:

  • 199 (53%) women with a HRQOL assessment prior to diagnosis underwent surgery.
  • Increases in physical and mental HRQOL domains were significantly associated with receipt of surgery.
  • There was no statistical significance in the relationship between HRQOL domains and OS.


Doll KM, Pinheiro LC, Reeve BB. Pre-diagnosis health-related quality of life, surgery, and survival in women with advanced epithelial ovarian cancer: A SEER-MHOS study. [Published online ahead of print December 14, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.12.005.