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Fertility-Sparing Surgery for Stage I Ovarian CA

Obstet Gynecol; ePub 2017 Jun 6; Melamed, et al

Fertility-sparing surgery was not associated with increased risk of death in young women with stage I epithelial ovarian cancer when compared with conventional surgery, a new study found. The cohort study identified women aged <40 years diagnosed with stage IA and unilateral IC epithelial ovarian cancer between 2004 and 2012. Primary outcome was time from diagnosis to death. Researchers found:

  • 1,726 women were included; 825 (47.8%) underwent fertility-sparing surgery.
  • 30 deaths were observed among women who underwent fertility-sparing surgery and 37 deaths among propensity-matched women who underwent conventional surgery after a median follow-up of 63 months.
  • Fertility-sparing surgery was not associated with hazard of death (HR 0.80).
  • The probability of survival 10 years after diagnosis was 88.5% in the fertility-sparing group and 88.9% in the conventional surgery group.

Citation:

Melamed A, Rizzo AE, Nitecki R, et al. All-cause mortality after fertility-sparing surgery for stage I epithelial ovarian cancer. [Published online ahead of print June 6, 2017]. Obstet Gynecol. doi:10.1097/AOG.0000000000002102.