Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Endosalpingiosis Associated with Ovarian Cancer?

Gynecol Oncol; ePub 2016 Jun 3; Esselen, Terry, et al

There is more likely to be a diagnosis of endometriosis, uterine, and ovarian cancers among women with endosalpingiosis (ES) compared to those without ES at the time of gynecologic surgery. This according to a study of 58,161 patients from the Gynecologic Surgery Cohort (GSC) from 1998 to 2013 who underwent gynecologic surgery for the presence of ES. Demographic and clinical characteristics were collected for patients with pathologically confirmed ES (n=838). Researchers found:

• Concurrent endometriosis, uterine cancer, and ovarian cancer were observed more frequently in women with ES.

• Women from the GSC with ES and ovarian cancer were more likely to have serous borderline (OR=10.2), clear cell (OR=3.0), and invasive mucinous tumors (OR=5.0) when compared to ovarian cancer cases from the New England Case Control Study (NECC) without ES, after accounting for age, race, menopausal status, parity, tubal ligation, and endometriosis.

Citation: Esselen KM, Terry KL, Samuel A, et al. Endosalpingiosis: More than just an incidental finding at the time of gynecologic surgery? [Published online ahead of print June 3, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.05.036.