Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Elderly Women and Endometrial Cancer

A look at treatment and survival

Elderly women with high-grade endometrial cancer were less likely than younger women to be treated with surgery, chemotherapy, or radiation, according to a cohort study of 20,486 patients who were stratified by age: younger than 55 years, 55 to 64, 65 to 74, 75 to 84, and ≥85 years. Researchers found:

• Patients < 55 years had surgery more frequently compared to patients 75 to 84 years, and 85 years or older, and a higher rate of lymph node dissection.

• Women < 55 years were more likely to receive chemotherapy compared with those 75 to 84 years and ≥85 years.

• In women with stage III disease, women 75 to 84 years had a twofold higher risk of death (HR, 2.38), and those ≥85 years had a threefold higher risk (HR, 3.16) compared with patients < 55 years.

• Patients with stage IV and age 75 to 84 years had a 24% increased risk of death (HR, 1.24) and those ≥85 years had a 52% increased risk (HR, 1.52).

Citation: Rauh-Hain JA, Pepin KJ, Meyer LA, et al. Management for elderly women with advanced-stage, high-grade endometrial cancer. [Published online ahead of print November 5, 2015]. Obstet Gynecol. doi: 10.1097/AOG.0000000000001140.