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Comparing Cervical Cytology and Histology

Results: HPV-vaccinated patients vs unvaccinated

Fewer high-grade lesions on both cytology and histology patients were reported by individuals presenting for colposcopic evaluation of abnormal cytology who had previously received the HPV vaccine when compared with HPV-unvaccinated women in a study of 1,662 patients aged 26 years or younger. Cytology and histology results were compared between previously HPV-vaccinated and unvaccinated women to determine if there was a difference in the severity of subsequent cytologic or pathologic specimens. In the study, women who previously received at least 1 dose of the HPV vaccine had:

• 53% lower odds of presenting with high-grade cytology (adjusted OR=0.47) compared with unvaccinated women.

• 36% lower odds of presenting with cervical intraepithelial neoplasia 2 or 3 or worse histology compared with unvaccinated women. (adjusted OR=0.64).

Citation: Dorton BJ, Vitonis AF, Feldman S. Comparing cervical cytology and histology among human papillomavirus-vaccinated and unvaccinated women in an academic colposcopy clinic. Obstet Gynecol. [Published online ahead of print September 3, 2015]. doi: 10.1097/AOG.0000000000001011.