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Bilateral Oophorectomy and Multimorbidity

Mayo Clin Proc; ePub 2016 Sep 29; Rocca, et al

There was a higher risk of multimorbidity among women who have undergone bilateral oophorectomy, however, several of these associations were reduced in women who received estrogen therapy, a recent study found. This population-based cohort study identified premenopausal women who underwent bilateral oophorectomy before age 50 years between January 1, 1988, and December 31, 2007. Each patient was randomly matched to a referent woman born in the same year who had not undergone bilateral oophorectomy. Rate of accumulation of 18 common chronic conditions over a median of ~14 years of follow-up was studied. Researchers found:

  • Women who underwent bilateral oophorectomy experienced an increased risk of subsequent multimorbidity despite having a higher multimorbidity burden at the time of oophorectomy.
  • After adjustments for 18 chronic conditions present at baseline, women who underwent oophorectomy before age 46 years experienced an increased risk of depression, hyperlipidemia, cardiac arrhythmias, coronary artery disease, arthritis, asthma, COPD, and osteoporosis.
  • There was also an accelerated rate of accumulation of the 18 chronic conditions considered together (HR, 1.22).
  • Several of these associations were reduced in women who received estrogen therapy.


Rocca WA, Gazzuola-Rocca L, Smith CY, et al. Accelerated accumulation of multimorbidity after bilateral oophorectomy: A population-based cohort study. [Published online ahead of print September 29, 2016]. Mayo Clin Proc. doi:10.1016/j.mayocp.2016.08.002.