Clinical Edge

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Alcohol Consumption and Ovarian Ca Risk

Comparing lifetime and type of consumption

Higher levels of wine consumption were generally associated with ovarian cancer risk reductions, and these reductions may be stronger for red wine, according to a study of 1,144 invasive epithelial ovarian cancer cases and 2,513 controls in a population-based, case-control study. The study investigated adult lifetime and type (beer, wine, spirits) of consumption and risk and determined:

• Wine consumption was associated with a risk reduction (aOR=0.67) relative to non-drinkers, but not beer (aOR=1.06), or spirits (aOR=0.98).

• The reduced risk was stronger for exclusive red wine drinkers (aOR=0.44) than white wine drinkers (aOR=0.79).

• Wine consumption initiated prior to age 50 was associated with a risk reduction, but not drinking initiated after 50 years of age.

• Guideline concordant alcohol consumption does not increase ovarian cancer risk.

Citation: Cook LS, Leung ACY, Swenerton K, et al. Adult lifetime alcohol consumption and invasive epithelial ovarian cancer risk in a population-based care-control study. [Published online ahead of print December 12, 2015]. Gynecol Oncol. doi: 10.1016/j.ygyno.2015.12.005.