In patients with stage I high-intermediate risk endometrial cancer (EC), surgery plus adjuvant radiation therapy (RT) showed a significant 4.1% improvement in 5-year overall survival (OS) compared to surgery alone, a recent study found. This national cancer database analysis included 33,600 patients that met criteria for those diagnosed with FIGO (2009) Stage I endometrioid adenocarcinoma from 1998 to 2012 and who underwent surgery ± adjuvant RT. Researchers found:
- 18,070 (53.8%) patients received surgery alone; 15,530 (46.2%) patients received surgery plus adjuvant RT.
- 42.4% of patients who received adjuvant RT received external beam RT, 44.7% brachytherapy, and 13.1% received both.
- 5-year OS was 79.2% for the surgery alone group; 83.3% for the surgery plus adjuvant RT group.
- Adjuvant RT was independently associated with improved OS vs surgery alone (HR, 0.7).
Gupta V, McGunigal M, Prasad-Hayes M, Kalir T, Liu J. Adjuvant radiation therapy is associated with improved overall survival in high-intermediate risk stage I endometrial cancer: A national cancer data base analysis. [Published online ahead of print October 25, 2016]. Gynecol Oncol. doi:10.1016/j.ygyno.2016.10.028.
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Maternal Factors in Cervical Cancer Prevention, Womens Health Issues; ePub 2019 Jan 10; Charlton, et al
Combined Gynecologic Ca & Pelvic Floor Dysfunction Surgery, Female Pelvic Med Reconstr Surg; ePub 2018 Oct 22; McConnell, et al