Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Consider Drug Treatment in Late-Life Women With Osteoporosis

Key clinical point: Medical treatment to prevent osteoporotic hip fracture in women over age 80 likely is worthwhile.

Major finding: Five-year hip fracture probability was 13% among women with osteoporosis and 4% among women without osteoporosis but at high fracture risk.

Study details: A prospective cohort study of 1,528 women 80 years and older who were potential candidates for osteoporosis drug treatment.

Disclosures: Dr. Cynthia M. Boyd reported receiving royalties from UpToDate and a grant from the National Institutes of Aging Dr. Katie L. Stone reported receiving grant support from Merck, and Dr. Lisa Langsetmo reported receiving grants from the National Institutes of Health and Merck. No other authors reported any relevant financial disclosures. The Study of Osteoporotic Fractures was supported by NIH and grants from NIA.


Ensrud KE et al. JAMA Intern Med. 2019 Jun 17. doi: 10.1001/jamainternmed.2019.0682.