Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

No Mortality Reductions Found With Osteoporosis Drugs

Key clinical point: Osteoporosis drugs are not associated with reduced mortality risk.

Major finding: Mortality rates were similar between patients taking osteoporosis drugs and those on placebo.

Study details: A meta-analysis of 38 clinical trials involving a total of 101,642 participants.

Disclosures: One author reported receiving grants and personal fees from a pharmaceutical company during the conduct of the study, and another reported receiving grants and personal fees outside the submitted work. No other conflicts of interest were reported.


Cummings SR et al. JAMA Intern Med. 2019 Aug 19. doi: 10.1001/jamainternmed.2019.2779.