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Lifestyle program improves chance of spontaneous conception for women with obesity

Key clinical point: A lifestyle intervention program targeting healthy eating and physical activity improved women with obesity’s chances of spontaneously conceiving after at least 6 months, and women with polycystic ovary syndrome (PCOS) appeared to benefit more from the program.

Major finding: The researchers looked at the spontaneous pregnancy rate and found women who received the intervention had nearly three times the rate of spontaneous pregnancy rate, compared with women in the control group (33% vs. 12%; P = .01), while women with PCOS in the lifestyle program had nearly five times the rate of spontaneous pregnancy, compared with the control group (27% vs. 6%; P = .02). Women without PCOS in the lifestyle program had twice the increased likelihood of spontaneous pregnancy, but the results were not significant (44% vs. 23%; P = .15).

Study details: A randomized controlled trial of 130 patients with obesity, with and without PCOS, who received a lifestyle intervention or usual care for infertility for at least 6 months.

Disclosures: The Fit-For-Fertility program was funded by an unrestricted grant from Ferring.


Baillargeon J-P et al. ASRM 2019, Abstract O-95.