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FRAX With BMD May Not be Accurate for Women With Diabetes

Key clinical point: When bone mineral density was included, both major osteoporotic fractures and hip fractures tended to be underestimated by FRAX in women with diabetes.

Major finding: The FRAX predictive tool underestimated major osteoporotic fractures and hip fractures in women with diabetes when bone mineral density was included (11 observed vs. 4 observed; 6 observed vs. 1 predicted, respectively). Hip fractures were accurately estimated in the women with normoglycemia and impaired fasting glucose.

Study details: The data come from 566 women aged 40-90 years.

Disclosures: The study was supported in part by the Victorian Health Promotion Foundation, National Health and Medical Research Council Australia, and the Geelong Region Medical Research Foundation. Two researchers were supported by university postgraduate rewards and one researcher was supported by a researcher postdoctoral research fellowship. The remaining researchers reported no relevant financial conflicts.


de Abreu LLF et al. Bone Reports. 2019 Aug 13. doi: 10.1016/j.bonr.2019.100223.