Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Some Peripartum Depression Patients Face Refractory Illness

Key clinical point: Women with peripartum depression and a history of depression were 50% more likely to be resistant to treatment than women who developed incident peripartum depression.

Major finding: About 5% of pregnant women with peripartum depression experience treatment-resistant depression.

Study details: The data come from a retrospective cohort study of a large U.S. claims database including 3,207,684 pregnant women, of whom 2.5% had a diagnosis of peripartum depression.


Cepeda MS et al. BMC Pregnancy Childbirth. 2019. doi: 10.1186/s12884-019-2462-9.