Clinical Edge

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Oral Contraceptive Use & Fracture Risk

Greater risk near menopausal transition?

There was no association between the use of oral contraceptives (OC) and fractures near the menopausal transition in the decade before menopause or after age 38. This according to a study of 1,204 case women aged 45 to 59 years with incident fractures, and 2,275 control women. Study results included:

• The most common fracture site for cases was the wrist/forearm (32%).

• Adjusted fracture risk did not differ between cases vs controls for OC use in the 10 years before menopause (OR=0.90), for OC use after age 38 (OR=0.94), and for duration of use, or for other OC exposures.

• For women considering OC use at these times, fracture risk did not appear to be either reduced or increased.

Citation: Scholes D, LaCroix AZ, Hubbard RA, et al. Oral contraceptive use and fracture risk around the menopausal transition. [Published online ahead of print January 8, 2016]. Menopause. doi: 10.1097/GME.0000000000000595.