Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

New Levonorgestrel-releasing Intrauterine System

Efficacy and safety results

A new 52-mg levonorgestrel-releasing intrauterine contraceptive system (LNG20) is both safe and effective for nulliparous and parous women for at least 3 years, according to a study of 1,600 women aged 16 to 45 and 36 to 45, including 1,011 nulliparous and 438 obese women. Researchers found:

• Successful placement occurred in 97.9% of participants.

• Six pregnancies occurred, four of which were ectopic.

• Cumulative life-table pregnancy rate was 95% through 3 years.

• Of women who discontinued use and desired pregnancy, 86.8% conceived spontaneously within 12 months.

Citation: Eisenberg DL, Schreiber CA, Turok DK, Teal SB, Westhoff CL, Creinin MD. Three-year efficacy and safety of a new 52-mg levonorgestrel-releasing intrauterine system. Contraception; 2015;92(1):10-16. doi: 10.1016/j.contraception.2015.04.006.